Day: November 8, 2021

[PubMed] [Google Scholar] 4. through AKT-independent, mTORC1-dependent effects on p70S6K, ribosomal protein S6 and 4E-BP1 phosphorylation. Moreover, inhibition of mTORC1/2 inhibited cell proliferation as profoundly as single-agent inhibition of either BRAFV600E or PI3′-kinase signaling. These data reveal a mechanism by which BRAFV600E and PI3′-kinase signaling cooperate to regulate melanoma proliferation through AKT-independent effects on protein […]