Day: November 21, 2021

N-BPs hinder farnesyl pyrophosphate synthase specifically, an integral enzyme in the mevalonate pathway.3 This prevents the biosynthesis of isoprenoids essential for the prenylation and, hence, membrane features and localisation of little guanosine triphosphatases that are crucial for osteoclast activity and success.3 Non-N-BPs trigger the intracellular accumulation of the cytotoxic analogue of adenosine triphosphate that induces […]