Thus, sequestration of MPO by perlecan, and consequent localization of oxidant production to this target, potentiates oxidative damage to the perlecan protein core. an Ethynylcytidine impairment of its ability to support endothelial cell adhesion, with this observed at a pathologically-achievable oxidant dose of 425 nmol oxidant/mg protein. In contrast, the heparan sulfate chains of HOCl/HOBr-modified […]