2004;18:2225C2230. is continually earmarked for proteasomal degradation by the Axin complex: Axin provides scaffolding for glycogen synthase kinase 3 (GSK3) to phosphorylate the N-terminus of -catenin (after priming by casein kinase 1, CK1), thus generating a phospho-degron recognized by the ubiquitin ligase adaptor -TrCP (2). This process relies on the Adenomatous polyposis coli (APC) tumor […]