J. as a nucleation site for the formation of WS3 signaling complexes, (ii) endosomal EGFR signaling is sufficient to activate the major signaling pathways leading to cell proliferation and survival, and (iii) endosomal EGFR signaling is sufficient to suppress apoptosis induced by serum withdrawal. The growth-stimulatory signal of epidermal growth factor (EGF) is definitely mediated […]