The figures were prepared with the program PyMOL (48). EPI consists of the p185her2/neuECD subdomain I (residues 1172) and the 1st C2 module (residues 173192) of subdomain II. This model reveals a mechanism for mAbs to drive the receptors into the internalization/degradation path from your inactive hypophosphorylated tetramers created dynamically by active dimers during a […]