Recently, Bulavinet al(21) reported that Wip1-null mouse button embryonic fibroblasts exhibited significant p16 build-up and lowered cyclin-dependent kinase 4 activity through p38MAPK signaling within a p53-independent fashion. In summary, the latest study indicated that Wip1 was frequently overexpressed and linked to the progression of NSCLC, that might serve a necessary role inside the p38MAPK/p53/p16 signaling […]