[PubMed] [Google Scholar] 4. through AKT-independent, mTORC1-dependent effects on p70S6K, ribosomal protein S6 and 4E-BP1 phosphorylation. Moreover, inhibition of mTORC1/2 inhibited cell proliferation as profoundly as single-agent inhibition of either BRAFV600E or PI3′-kinase signaling. These data reveal a mechanism by which BRAFV600E and PI3′-kinase signaling cooperate to regulate melanoma proliferation through AKT-independent effects on protein […]
The looks of conditional null mice had not been not the same as controls aside from humble articular deformities in the femoral-tibial joint, that have been confirmed by contact radiography (Fig. the osteopenia seen in conditional null mice. Osteoclast amount was elevated in 1-month-old male conditional null mice, and bone tissue formation was elevated in […]